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Improved process robustness, product quality and biological efficacy of an anti-CD52 monoclonal antibody upon pH shift in Chinese hamster ovary cell perfusion culture

Article ID Journal Published Year Pages File Type
6495469 Process Biochemistry 2018 33 Pages PDF
Keywords
antibody-dependent cell-mediated cytotoxicitycomplement-dependent cytotoxicityCharge heterogeneityPerfusionGlycosylation
Related Topics
Physical Sciences and Engineering Chemical Engineering Bioengineering
Preview
Improved process robustness, product quality and biological efficacy of an anti-CD52 monoclonal antibody upon pH shift in Chinese hamster ovary cell perfusion culture
Authors
Chen Zheng, Chao Zhuang, Yantian Chen, Qiang Fu, Hui Qian, Yanchao Wang, Jinyan Qin, Xiang Wu, Nianmin Qi,
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Journal
Process Biochemistry
Journal: Process Biochemistry
Related Categories
antibody-dependent cell-mediated cytotoxicity
complement-dependent cytotoxicity
Charge heterogeneity
Perfusion
Glycosylation
Bioengineering
Catalysis
Chemical Engineering (General)
Chemical Health and Safety
Colloid and Surface Chemistry
Filtration and Separation
Fluid Flow and Transfer Processes
Process Chemistry and Technology
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