Biotransformation of major flavonoid glycosides in herb epimedii by the fungus Cunninghamella blakesleana

- Icariin (1), epimedin C (2), epimedoside A (3), epimedin A (4) and epimidin B (5) could be transformed to rare and bioactive products with the yield of above 95%.
- Some transformed products showed exhibited the more significant anti-osteoporosis activity.
- Our investigation provided an efficient biotransformation approach to enrich the rare and more biological active flavonoids in herb epimedi.