Article ID Journal Published Year Pages File Type
6531361 Journal of Molecular Catalysis B: Enzymatic 2013 43 Pages PDF
Abstract

- First study of the mechanisms of glucose and xylose activation of a β-glucosidase.
- The monomeric enzyme has distinct catalytic (CS) and modulator (MS) binding sites.
- Glucose binding to the MS induces conformational changes that stimulate catalysis at CS.
- Glucose and substrate competition for the CS leads to inhibition at high glucose concentrations.
- Stimulation by glucose and xylose is not synergic, they compete for the same sites.
Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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