Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6577 | Biomaterials | 2012 | 13 Pages |
Abstract
A strategy of preparing composite micelles containing both cisplatin(IV) prodrug and paclitaxel was developed, i.e., synthesizing a cisplatin(IV) conjugate and a paclitaxel conjugate starting with the same biodegradable and amphiphilic block copolymer, and co-assembling the two conjugates. The composite micelles could release effective anticancer drug cisplatin(II) upon cellular reduction and PTX via acid hydrolysis once they came into the cancerous cells. Moreover, the composite micelles displayed synergistic effect in vitro and the combination therapy in micellar dosage-form led to reduced systematic toxicity and enhanced antitumor efficacy in vivo.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Haihua Xiao, Haiqin Song, Qiang Yang, Haidong Cai, Ruogu Qi, Lesan Yan, Shi Liu, Yonghui Zheng, Yubin Huang, Tongjun Liu, Xiabin Jing,