Energetic vs structural effects of aminoalkyl substituents in the morpholine

The combination of experimental and computational data determined in this work for morpholine derivatives, together with other available in the literature for related molecules, enabled the analyses of the energetic effects associated with the substitution of the hydrogen of the morpholine amino group by substituents aminoalkyl and alkyl, as well as the establishment of incremental schemes for the determination of the gas-phase enthalpies of formation.