| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6773 | Biomaterials | 2012 | 8 Pages |
Abstract
We have developed a straightforward method to prepare 1st and 2nd generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, in vitro. These results provide insights into the effect of HYDRAmer multivalency on biological interactions for therapeutic applications.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Giuseppe Lamanna, Julie Russier, Hélène Dumortier, Alberto Bianco,