Article ID Journal Published Year Pages File Type
6779 Biomaterials 2012 8 Pages PDF
Abstract

The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1–40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ1–40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis. It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ1–40 fibrillogenesis.

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Physical Sciences and Engineering Chemical Engineering Bioengineering
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