| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6821935 | Schizophrenia Research | 2018 | 9 Pages |
Abstract
This study simultaneously showed reduction in GABA and elevation in Glx in first-episode schizophrenia subjects, and this might provide insights on explaining the disruption of modulation between GABAergic interneurons and glutamatergic neurons. Elevated Cho might indicate increased membrane turnover; whereas reduced mI might reflect dysfunction of the signal transduction pathway. In vivo Glx and GABA revealed their diagnostic potential for schizophrenia.
Keywords
ACCPANSSROCWAIS-RNMDARSingle voxel spectroscopyNaAGad67GLNFFEMEGA-PRESSFWHMSVSAUCGlxN-acetyl aspartateT1-weightedFirst-episode schizophreniagamma-aminobutyric acidFast field echoChoBiomarkerQUESTecho timeRepetition timePearson correlation coefficientProton magnetic resonance spectroscopyfull width at half maximumconfidence intervalanterior cingulate cortexgrey matterwhite matterCerebrospinal fluidCSFReceiver operator characteristicsPRESSpositive and negative syndrome scaleWechsler Adult Intelligence Scale-Revisedarea under curveMyo-inositolpoint resolved spectroscopycreatinehealthy controlCholineGABAGluglutamateglutamine
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Authors
P.W. Chiu, Simon S.Y. Lui, Karen S.Y. Hung, Raymond C.K. Chan, Queenie Chan, P.C. Sham, Eric F.C. Cheung, Henry K.F. Mak,