Illness versus substance use effects on the frontal white matter in early phase schizophrenia: A 4Â Tesla 1H-MRS study

The specific effect of illness on white matter might indicate a decreased synthesis of membrane phospholipids or alternatively, reduced membrane cellular density. In terms of limitations, this study did not include patients without a lifetime history of substance use (non-users), and the specific effect of each substance used could not be studied separately.