Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6822703 | Schizophrenia Research | 2016 | 4 Pages |
Abstract
The latest genome-wide association study of schizophrenia identified 108 distinct genomic loci that contribute to schizophrenia. Brain development and function depend on the precise regulation of gene expression. The expression of many genes is differentially regulated across brain regions and developmental time points. We investigated the specific gene expression patterns arising from the 108 schizophrenia-associated loci using multiple publicly available databases and multiple regional brain datasets from developing and adult post-mortem human brains. The temporal-spatial expression analysis revealed that the genes in these loci were intensively enriched in the cortex during several developmental stages. These cortex-specific genes were particularly expressed in the fetal brain and adult neocortex.
Keywords
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Kazutaka Ohi, Takamitsu Shimada, Yusuke Nitta, Hiroaki Kihara, Hiroaki Okubo, Takashi Uehara, Yasuhiro Kawasaki,