Longitudinal change in neurocognition and its relation to symptomatic and functional changes over 2Â years in individuals at clinical high-risk for psychosis

Our findings show that semantic fluency seems to be a neurocognitive indicator reflecting clinical courses in CHR individuals. The longitudinal relationship of negative symptoms and functioning with semantic fluency may represent ongoing pathological processes in neural systems involving aberrant fronto-temporal interaction in the early phase of schizophrenia.