Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6822982 | Schizophrenia Research | 2016 | 8 Pages |
Abstract
White matter deficits were validated in the present study by a relatively large sample of medication naïve and first episode schizophrenia patients. They could be associated with negative symptoms and cognitive impairment, whereas improvement in white matter integrity of left superior longitudinal fasciculus correlated with improvement in psychosis and processing speed. Further examination of treatment-related changes in white matter integrity may provide clues to the mechanism of antipsychotic response and provide a biomarker for clinical studies.
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Authors
Botao Zeng, Babak A. Ardekani, Yingying Tang, Tianhong Zhang, Shanshan Zhao, Huiru Cui, Xiaoduo Fan, Kaiming Zhuo, Chunbo Li, Yifeng Xu, Donald C. Goff, Jijun Wang,