Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10Â year follow-up study in the OPUS cohort

Trajectories of illness for positive and negative symptoms were heterogeneous among people with first episode psychosis. Positive symptoms showed a general pattern of reduction and stabilization over time while negative symptoms typically showed less variation over the ten years. Results have implications for the focus, timing and length of interventions in first episode psychosis.