| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6823839 | Schizophrenia Research | 2015 | 6 Pages |
Abstract
The present study provides evidence that FEP is characterized by an inverse relationship between lowered activity of the anti-inflammatory/antioxidant enzyme PON1 and increased cytokine levels, including IL-6, IL-4 and IL-10. It is hypothesized that lowered PON1 activity may play a role in the immune-inflammatory response that accompanies FEP and that increased cytokine levels may further modulate PON1 activity.
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Authors
Francis Fregonesi Brinholi, Cristiano Noto, Michael Maes, Kamila Landucci Bonifácio, Elisa Brietzke, Vanessa Kiyomi Ota, Ary Gadelha, Quirino Cordeiro, Sintia Iole Belangero, Rodrigo Affonseca Bressan, Heber Odebrecht Vargas, Luciana Higachi,