Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6824971 | Schizophrenia Research | 2014 | 7 Pages |
Abstract
This study provides unique evidence that suicide risk directly relates to PFC-based circuit dysfunction during goal-representation, in a major mental illness with significant suicide rates. Among those with suicidal ideation, the overt expression in suicidal behavior may stem from impairments in premotor cortex support of action-planning as an expression of control. Further work should address how PFC-based control function changes with risk over time, whether this brain-behavior relationship is specific to schizophrenia, and address its potential utility as a biomarker for interventions to mitigate suicide risk.
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Authors
Michael J. Minzenberg, Tyler A. Lesh, Tara A. Niendam, Jong H. Yoon, Remy N. Rhoades, Cameron S. Carter,