Article ID Journal Published Year Pages File Type
6824971 Schizophrenia Research 2014 7 Pages PDF
Abstract
This study provides unique evidence that suicide risk directly relates to PFC-based circuit dysfunction during goal-representation, in a major mental illness with significant suicide rates. Among those with suicidal ideation, the overt expression in suicidal behavior may stem from impairments in premotor cortex support of action-planning as an expression of control. Further work should address how PFC-based control function changes with risk over time, whether this brain-behavior relationship is specific to schizophrenia, and address its potential utility as a biomarker for interventions to mitigate suicide risk.
Related Topics
Life Sciences Neuroscience Behavioral Neuroscience
Authors
, , , , , ,