Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6825085 | Schizophrenia Research | 2014 | 7 Pages |
Abstract
Prenatal and family environmental disruptions are elevated in families with a first-degree relative with schizophrenia. Findings support our proposed 'polygenic neurodevelopmental diathesis-stress model' whereby psychosis susceptibility (and resilience) involves the independent and synergistic confluence of (temporally-sensitive) biological and environmental factors across development. Recognition of biological and social environmental influences across critical developmental periods points to key issues relevant for enhanced identification of psychosis susceptibility, facilitation of more precise models of illness risk, and development of novel prevention strategies.
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Authors
Deborah J. Walder, Stephen V. Faraone, Stephen J. Glatt, Ming T. Tsuang, Larry J. Seidman,