| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6825786 | Schizophrenia Research | 2013 | 8 Pages |
Abstract
Our finding of hyperactivation in WM and DMN areas indicates that siblings fail to adequately inhibit DMN activity during demanding cognitive tasks and subsequently hyperactivate WM areas. This failure may reflect dopamine hyperactivity in the striatum which prevents adequate DMN suppression needed for effective WM. This study provides support for the notion that aberrant WM and DMN activation patterns may represent candidate endophenotypes for schizophrenia.
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Authors
Max de Leeuw, René S. Kahn, Bram B. Zandbelt, Christian G. Widschwendter, Matthijs Vink,