Article ID Journal Published Year Pages File Type
6826381 Schizophrenia Research 2013 10 Pages PDF
Abstract
Dysbindin-1 null mice showed a decrease in the ready releasable pool of synaptic vesicles, decreases in quantal size, decreases in the probability of release and deficits in the rate of endo- and exocytosis compared with wild-type controls. Moreover, the dysbindin-1 null mice show decreases in the [Ca2 +]i,expression of L- and N-type Ca2 +channels and several proteins involved in synaptic vesicle trafficking and priming. Our results provide new insights into the mechanisms of action of dysbindin-1.
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