Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6827387 | Schizophrenia Research | 2011 | 5 Pages |
Abstract
Objective
We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia.
Method
MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions.
Results
The analysis revealed significant inverse correlations between ratings of the severity of delusions and volumes of the left claustrum and right insula. Significant correlations were not observed between cerebral GM volume and ratings of hallucinations.
Conclusion
The insula/claustrum region may be critical to the experience of delusions and more careful scrutiny of the claustrum in relation to schizophrenia appears warranted.
Keywords
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Nicola G. Cascella, Gwendolyn J. Gerner, Shaina C. Fieldstone, Akira Sawa, David J. Schretlen,