Reduced activation of superior temporal gyrus during auditory comprehension in young offspring of patients with schizophrenia

These data suggest that adolescents at risk for schizophrenia show reduced activation of the STG compared to control subjects during a language related task (listening). This finding adds support to the idea that abnormal development of the language related cortex is a marker of increased susceptibility to schizophrenia and that such deviant development may be mediated by familial/genetic factors.