Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6828412 | Schizophrenia Research | 2009 | 5 Pages |
Abstract
Acetyl-coenzyme A carboxylase α (ACACA) single-nucleotide polymorphism (SNP) (rs2229416) was significantly associated with hypertriglyceridemia, during exploration of antipsychotic direct effects on lipids. Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia. In the same sample (173 patients on olanzapine, quetiapine, chlorpromazine or mirtazapine [increasing the risk of hyperlipidemia] and 184 controls taking other antipsychotics), three (rs1266175, rs12453407 and rs9906543) of eight additional ACACA SNPs were significantly associated with hypertriglyceridemia in those taking drugs of interest, but not in controls. Five other ACACA SNPs, three additional NPY SNPs, and seven additional ACACB SNPs were not significant.
Keywords
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Francisco J. Diaz, Alexander Meary, Maria J. Arranz, Gualberto Ruaño, Andreas Windemuth, Jose de Leon,