Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6829251 | Schizophrenia Research | 2007 | 11 Pages |
Abstract
Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
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Authors
Peter F. Buckley, Sahebarao Mahadik, Anilkumar Pillai, Alvin Jr.,