Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6829602 | Schizophrenia Research | 2007 | 5 Pages |
Abstract
Analysis of the distribution of mitochondrial haplogroups in schizophrenia patients compared to their healthy fathers (202 pairs) resulted in an over-representation of the mtDNA lineage cluster, HV, in the patients (p = 0.01), with increased relative risk (odds ratio) of 1.8. Since mitochondrial DNA is small relative to nuclear DNA, a total mitochondrial genome analysis was possible in a hypothesis-free manner. However, mitochondrial DNA haplogroups are highly variable in human population and it will be necessary to replicate our results in other human ethnic groups.
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Authors
Shirly Amar, Alon Shamir, Ofer Ovadia, Monica Blanaru, Alon Reshef, Ilana Kremer, Marcella Rietschel, Thomas G. Schulze, Wolfgang Maier, R.H. Belmaker, Richard P. Ebstein, Galila Agam, Dan Mishmar,