Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6874614 | Journal of Computational Science | 2015 | 6 Pages |
Abstract
Epistasis, the interaction between genes, has become a major topic in molecular and quantitative genetics. It is believed that these interactions play a significant role in genetic variations causing complex diseases. Several algorithms have been employed to detect pairwise interactions in genome-wide association studies (GWAS) but revealing higher order interactions remains a computationally challenging task. State of the art tools are not able to perform exhaustive search for all three-locus interactions in reasonable time even for relatively small input datasets. In this paper we present how a hardware-assisted design can solve this problem and provide fast, efficient and exhaustive third-order epistasis analysis with up-to-date FPGA technology.
Keywords
Related Topics
Physical Sciences and Engineering
Computer Science
Computational Theory and Mathematics
Authors
Jan Christian Kässens, Lars Wienbrandt, Jorge González-DomÃnguez, Bertil Schmidt, Manfred Schimmler,