Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6897411 | European Journal of Operational Research | 2014 | 12 Pages |
Abstract
Half-life is a unique characteristic of radioactive substances used in a variety of medical treatments. Radioisotope F-18 used for diagnosing and monitoring many types of cancers has a half-life of 110Â minutes. As such, it requires careful coordination of production and delivery by manufacturers and medical end-users. To model this critical production and delivery problem, we develop a mixed integer program and propose a variant of a large neighborhood search algorithm with various improvement algorithms. We conduct several computational experiments to demonstrate the effectiveness of the proposed approach. The method when applied in a case study shows that improvement in terms of both time and cost is possible in the production and delivery of F-18.
Related Topics
Physical Sciences and Engineering
Computer Science
Computer Science (General)
Authors
Jongsung Lee, Byung-In Kim, Andrew L. Johnson, Kiho Lee,