| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6927 | Biomaterials | 2012 | 7 Pages |
Abstract
Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC50/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Lihong Liu, Yuan Huang, Siti Nurhanna Riduan, Shujun Gao, Yiyan Yang, Weimin Fan, Yugen Zhang,