Article ID Journal Published Year Pages File Type
69476 Journal of Molecular Catalysis B: Enzymatic 2015 7 Pages PDF
Abstract

•This is the first eco-efficient report for the synthesis of title compounds using biocatalysis.•Synthesis of pyrazole structural motifs expedited by fermenting baker's yeast.•The role of baker's yeast in the reaction mechanism has been studied.•Easy access of biologically important pyrazole structural cores from less reactive hydrazines and hydrazides.

An expeditious oxidative cyclocondensation reaction of hydrazines/hydrazides with 1,3-dicarbonyl compound was efficiently developed in aqueous medium using Saccharomyces cerevisae (baker's yeast) as a whole cell biocatalyst at room temperature. The method has been assigned using green chemistry measures and found to give a range of N-substituted pyrazoles with moderate to excellent yields (70–92%). The reaction progress was monitored by gas chromatography.

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Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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