Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6951258 | Biomedical Signal Processing and Control | 2016 | 11 Pages |
Abstract
The limitations of the available imaging modalities for prostate cancer (PCa) localization result in suboptimal protocols for management of the disease. In response, several dynamic contrast-enhanced imaging modalities have been developed, which aim at cancer detection through the assessment of the changes occurring in the tumor microenvironment due to angiogenesis. In this context, novel magnetic resonance dispersion imaging (MRDI) enables the estimation of parameters related to the microvascular architecture and leakage, by describing the contrast agent kinetics with a dispersion model. Although a preliminary validation of MRDI on PCa has shown promising results, parameter estimation can become burdensome due the convolution integral present in the dispersion model. To overcome this limitation, in this work we provide analytical solutions of the dispersion model in the time and frequency domains, and we implement three numerical methods to increase the time-efficiency of parameter estimation. The proposed solutions are tested for PCa localization. A reduction by about 50% of computation time could be obtained, without significant changes in the estimation performance and in the clinical results. With the continuous development of new technological solutions to boost the spatiotemporal resolution of DCE-MRI, solutions to improve the computational efficiency of parameter estimation are highly required.
Keywords
Related Topics
Physical Sciences and Engineering
Computer Science
Signal Processing
Authors
Simona Turco, Augustus J.E.M. Janssen, Cristina Lavini, Jean J. de la Rosette, Hessel Wijkstra, Massimo Mischi,