Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6952234 | Egyptian Journal of Basic and Applied Sciences | 2018 | 7 Pages |
Abstract
The objective of this study was to perform phytochemical screening, to determine the content of phenolic compound, to evaluate antioxidant, anti-inflammatory and antiangiogenic activities of ethanol, water-ethanol and water extracts of Lophira procera. Antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and phosphomolybdenum assay, anti-inflammatory activity by proteins denaturation inhibition and membranes stabilization test and antiangiogenic activity by chicken chorioallantoic membrane (CAM) method. The results showed that this plant is rich in saponins, polyphenols, tannins, total flavonoids, proanthocyanidins and coumarins. Extracts presented a strong antioxidant activity (IC50 values of 5.452â¯Â±â¯0.119â¯Î¼g/mL and 6.346â¯Â±â¯0.544â¯Î¼g/mL and respective AAI of 9.173â¯Â±â¯0.203 and 7.919â¯Â±â¯0.711). Excellent anti-inflammatory activity was also observed (IC50â¯=â¯16.952â¯Â±â¯1.897 and IC50â¯=â¯23.172â¯Â±â¯0.066â¯Î¼g/mL for inhibition of protein denaturation and membrane stabilization respectively). Finally, extracts manifested a very good anti-angiogenic activity (with inhibitions ranging from 57.142â¯Â±â¯0.124% to 100%). These biological activities are certainly due to high content of phenolic compound. This is the first study to report the phytochemical screening, the content of phenolic compound, the antioxidant, anti-inflammatory and antiangiogenic activities of extract derived from Lophira procera. The use of this plant in traditional medicine against ulcers, breast cancer, kidney and dental pain is therefore justified and its potential as a candidate for bioactive therapeutic molecule.
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Authors
Ngoua-Meye-Misso Rick-Leonid, Sima-Obiang Cédric, Ndong Jean De La Croix, Ondo Joseph Privat, Ovono Abessolo Felix, Obame-Engonga Louis-Clément,