Synthesis and evaluation of [N-(Substituted phenyl)-2-(3-substituted) sulfamoyl) phenyl)] acetamide derivatives as anticancer agents

A series of molecules containing sulfonyl and amide coupling structure were developed, synthesized and evaluated. Total 21 compounds having sulfonamide and amide groups are synthesized. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, Mass spectrum and the purity was checked through HPLC analysis. All synthesized compounds (4a-4u) were tested for their in vitro anticancer activity against a series of different cell lines like A549 (Lung Cancer cell), HeLa (Cervical), MCF-7 (Breast Cancer cell) and Du-145 (Prostate Cancer cell) respectively. The results of the anticancer activity revealed that most of the tested compounds showed moderate to good anticancer activity. Compounds 4d, 4k and 4s show promising anticancer activity in different cell lines.