Article ID Journal Published Year Pages File Type
69549 Journal of Molecular Catalysis B: Enzymatic 2015 6 Pages PDF
Abstract

•Microbial transformations of Astragalus saponins were investigated.•Two fungi were used as whole cell systems.•Each organism led to characteristic transformations with different substrates.•Eight molecules are introduced to the literature for the first time.

The microbial transformation of Astragalus sp. derived sapogenins, namely cycloastragenol, astragenol and cyclocanthogenol, by Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552 were investigated. The unique enzyme system of both fungi resulted hydroxylation, cyclization, dehydrogenation and oxidation reactions. Structures of the new metabolites were elucidated by 1-D (1H, 13C, NOESY), 2-D NMR (DQF-COSY, HMBC, HMQC, NOESY) and HR-MS analyses.

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Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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