| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 69677 | Journal of Molecular Catalysis B: Enzymatic | 2014 | 7 Pages |
•The biotransformations were catalyzed by enzymatic system of Aspergillus niger MB.•The reactions proceeded via a two-step mechanism.•Optically pure products were obtained.•Esters of 6-hydroxyflavanone were transformed to (−)-(S)-6,4′-dihydroxyflavanone.•6-Methoxyflavanone was transformed to (+)-(R)-6,4′-dihydroxyflavanone.
In the culture of Aspergillus niger MB, three racemic flavonoid derivatives (6-acetoxy-, 6-propionoxy-, and 6-butyryloxyflavanone) undergo microbial transformations resulting in optically pure (−)-(S)-6,4′-dihydroxyflavanone formation. In turn, biotransformation of (±)-6-methoxyflavanone by the same strain led to optically pure (+)-(R)-6,4′-dihydroxyflavanone. Besides the optically pure flavanones, the product of dehydration, 6-hydroxyflavone, was also formed.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
