Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
69796 | Journal of Molecular Catalysis B: Enzymatic | 2013 | 8 Pages |
•Candida antartica B lipase catalyzed highly enantioselective resolution of trans-2-(phenylthio)cyclohexanol.•Methyl tert-butyl ether provides an efficient medium for kinetic resolution.•The resolved hydroxy sulfides upon oxidation provide a very convenient method for obtaining chiral hydroxy sulfoxides which are otherwise difficult to obtain by traditional methods.•The configuration to the stereogenic centers assigned on the basis of single crystal X-ray analysis.
Candida antartica B (immobilized CAL-B) mediated resolutions of trans-2-(phenylthio)cyclohexanol derivatives using vinyl acetate as acylating agent and MTBE as solvent provide excellent enantioselectivity (up to >99%) and high yield of both the enantiomers in short reaction time.
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