Design and characterization of surfaces presenting mechanical nanoheterogeneities for a better control of cell-material interactions

- Colloidal lithography was used to create a rigid topographic nanostructure.
- This topography was covered with soft PDMS to create a surface mechanical contrast.
- Obtained surfaces had a limited topography and homogeneous surface chemistry.
- Mechanical contrast was evaluated using atomic force microscopy.
- Mechanical nanoheterogeneities are shown to direct MC3T3 cell response.