| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6979819 | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2014 | 10 Pages |
Abstract
⺠Plasmid DNA (pDNA) was efficiently encapsulated into biocompatible microgels. ⺠Plasmid DNA and an anticancer drug, doxorubicin, have been successfully released from pDNA microgels. ⺠The release of pDNA is capable of transfection in vitro resulting in the expression of p53 protein. ⺠The treatment with a pDNA/doxorubicin loaded microgel improves cancer cell apoptosis. ⺠We developed a novel pDNA vehicle for cancer treatment through the combined action of chemotherapy and gene delivery approach.
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Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Diana Costa, Artur J.M. Valente, M. Graça Miguel, João Queiroz,