Article ID Journal Published Year Pages File Type
6979961 Colloids and Surfaces A: Physicochemical and Engineering Aspects 2012 5 Pages PDF
Abstract
► A significant increase of bioavailability of promethazine is observed under the influence of caffeine. ► The character of changes in the first-pass effect of caffeine under the influence of promethazine is depended on the sequence of administration of drugs. ► We proposed formation of certain complexes of caffeine with surface active molecule of promethazine.
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Related Topics
Physical Sciences and Engineering Chemical Engineering Colloid and Surface Chemistry
Preview
Revealing of pharmacokinetic peculiarities of surface active drug promethazine in its interaction with caffeine in rabbits
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