| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 69897 | Journal of Molecular Catalysis B: Enzymatic | 2012 | 6 Pages |
The tandem use of laccases and lipases has been exploited for the preparative scale synthesis of enantiomerically enriched dimeric phenols.Laccase-catalyzed oxidation of 4-vinylphenol (3) in biphasic systems gave as main product the racemic compound 4.The enantiomerically enriched butanoate (+)-4b and acetate (−)-4a could be obtained by alcoholysis reactions catalyzed by porcine pancreatic lipase in organic solvent and subsequent acetylation.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Preparative scale synthesis of enantiomerically enriched dimeric phenols has been achieved by tandem use of laccases and lipases. ► Racemic compound 4 was the main product of laccase-catalyzed oxidation of 4-vinylphenol (3). ► Alcoholysis reactions catalyzed by porcine pancreatic lipase in organic solvent, followed by acetylation, gave the enantiomerically enriched butanoate (+)-4b and acetate (−)-4a.
