| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 69916 | Journal of Molecular Catalysis B: Enzymatic | 2013 | 5 Pages |
Several fungal species namely: Aspergillus niger, Aspergillus parasiticus, Penicillium funiculosum, Trigonopsis variabilis and two different strains of Fusarium oxysporum were tested toward racemic mixtures of following phosphonic acids: 1-amino-2-methylpropanephosphonic acid, 1-aminophenylmethanephosphonic acid and 1-amino-2-phenylethanephosphonic acid. Application of F. oxysporum strain (UW1) allowed obtaining optically pure S-isomer of 1-aminophenylmethanephosphonic acid and R-isomer of 1-amino-2-phenylethanephosphonic acid, whereas biotransformation of racemic mixture of 1-amino-2-methylpropanephosphonic acid with F. oxysporum strain (DSM 12646) cells resulted in obtaining pure enantiomer of R-configuration.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Fungal cells were applied to resolve racemic mixtures of α-aminophosphonic acids. ► This microbial transformation is considered as kinetically controlled bioconversion. ► The most potent appeared to be two different strains of Fusarium oxysporum. ► Optically pure enantiomers of ValP, PheP and PhgP were obtained.
