Kinetic resolution of 5H-pyrrolo[1,2-a]imidazol-7-ol, 6,7-dihydro under continuous flow conditions: An intermediate for chiral ionic liquids synthesis

In this letter we disclosed an efficient method for the kinetic resolution of an imidazole derivate both in batch and continuous flow conditions. This imidazole derivative has been described to have important applications in different fields and it was obtained, in its enantiomerically pure form, with excellent enantiomeric excess, good yields and short time using continuous flow conditions.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Biocatalyzed continuous flow process. ► Kinetic resolution of racemic imidazole derivatives. ► Fast and eficiente method for chiral ionic liquids synthesis.