Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
69926 | Journal of Molecular Catalysis B: Enzymatic | 2013 | 5 Pages |
Abstract
•1,3-Dipolar cycloaddition reaction and bioreduction with carrot bits in one-pot.•Excellent enantiomeric excesses were obtained for all reactions (>99%).•Only water as solvent was needed for all reactions.•Cheap catalysts were employed.
A one-pot, two-step procedure combining 1,3-dipolar cycloaddition and an enantioselective reduction mediated by Daucus carota (carrot root) is described. The synthesis was accomplished by first employing the biocatalyst followed by a “click” reaction under very mild conditions to yield the corresponding chiral disubstituted 1,2,3-triazoles.
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Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Camila de Souza de Oliveira, Kleber Tellini de Andrade, Alvaro Takeo Omori,