| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6997930 | Journal of Colloid and Interface Science | 2014 | 12 Pages |
Abstract
- Artemisinin-loaded nanoparticles (ALPLGA) were developed by Box Behnken design.
- An initial burst was followed by controlled release of artemisinin at pH 5.5, 7.4.
- IC50 for intracellular amastigotes was 2.9 fold lower with ALPLGA than artemisinin.
- ALPLGA significantly reduced the infected macrophages with restoration of NO levels.
- ALPLGA were non-toxic to macrophages and may have potential for drug delivery.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Muzamil Yaqub Want, Mohammad Islamuddin, Garima Chouhan, Anjan Kumar Dasgupta, Asoke Prasun Chattopadhyay, Farhat Afrin,