Lipase-catalyzed esterification of steric hindered fructose derivative by continuous flow and batch conditions

The lipase catalyzed sugar ester synthesis is an interesting strategy for producing biodegradable, non-ionic surfactants. The main disadvantage of this protocol is the long reaction time required for achieving moderated to good yields. Here, we report the esterification of steric hindered fructose derivative where important variables for batch conditions were identified by the use of a RSM protocol and then translated to the continuous flow regime with high conversions and short residence times.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Biocatalysis under continuous flow conditions. ► Lipase catalyzed esterification of protected sugars. ► Gain in productivity using packed bed reactors. ► Synthesis of sugar esters using packed bed reactors.