Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7001099 | Journal of Colloid and Interface Science | 2011 | 8 Pages |
Abstract
⺠Large area protein micro-arrays with feature size down to 8 à 8 μm2 square spots could be clearly imaged by imaging ellipsometry. ⺠By using different patterns, 100-1600 label-free protein spots were imaged simultaneously. ⺠The thickness changes during the formation of protein patterns were quantitatively monitored on the 32 à 32 μm2 square spots. ⺠Quantitatively ellipsometric measurements were performed on protein arrays with densities above 5 à 104 spot/cm2. ⺠A single spot detection limit as low as 1.2 pg/spot was achieved.
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Authors
Meng-Jie Chang, Chao-Ran Pang, Jun Liu, Hua Bai, Jun Deng, Zhu-Guo Xu, Hao-Li Zhang,