| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 70023 | Journal of Molecular Catalysis B: Enzymatic | 2013 | 6 Pages |
Xylitol capric acid esters are widely applied due to their surfactant properties. In this study, site-specific xylitol dicaprate ester was obtained in a solvent-free system in the presence of lipase Candida sp. 99-125. UPLC-MS, and NMR analysis revealed that diesters were substituted at the C-1, C-5 positions. A series of experiments defined the optimum conditions of temperature, water content, loading of lipase, molar ratio and time course. The yield of xylitol esters reached 70% after 4 successive additions of xylitol. A subsequent coupling reaction and separation was introduced and significantly increased the yield of esters and also reduced the cost of the process. The lipase could be reused for 5 times with the yield of esters still reaching 50%.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Xylitol ester was synthesized in a solvent free system with low reaction temperature. ► Coupling reaction and separation significantly lowered the cost of the process. ► Lipase Candida sp. 99-125 was used as catalyst, and it could be reused for 5 times. ► Site-specific xylitol dicaprate ester was major products in the process.
