Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
700325 | Control Engineering Practice | 2007 | 13 Pages |
Abstract
The paper presents a fed-batch fermentation technique for bioreactors operating close to their maximum oxygen transfer capacity. The method combines the advantages of the probing feeding strategy and the temperature limited fed-batch technique. When the maximum oxygen transfer capacity of the reactor is reached, the temperature is decreased to lower the oxygen demand. To achieve a good control of the dissolved oxygen a mid-ranging controller manipulating the stirrer speed and the temperature is used. The feeding strategy is analysed and it is also illustrated by simulations and an experiment.
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Authors
S. Velut, L. de Maré, P. Hagander,