| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 702772 | Diamond and Related Materials | 2012 | 4 Pages |
The development of glioma-specific nanoparticles is an area of intense research recently. Fluorescent nanodiamonds (FND) as optical probes to image biological systems have attracted considerable attention. In this paper, the glioma-specific nanoparticles FND-conjugated with BmK CT, a key chlorotoxin-like peptide isolated from the scorpion venom of Buthus martensii Karsch, were developed. The receptor-mediated uptake of FND-BmK CT bioconjugates into rat C6 glioma cells and direct tumor visualization were confirmed by confocal fluorescence assay. Moreover, FND-BmK CT had high inhibition rate during the migration of rat C6 glioma cells by in vitro wound healing assay. These glioma-specific multifunctional nanoparticles FND-BmK CT might be responsible for the development of more effective therapeutic agents in clinical treatment of glioma.
► Development of glioma-specific nanoparticle is an area of intense research in 2010. ► FND-BmK CT exhibits a direct tumor visualization. ► FND-BmK CT has high inhibition rate during the migration of C6 cells. ► FND-BmK CTs may be therapeutic agents in treatment of glioma. ► FND-BmK CT may provide a therapeutic option for a variety of MMP-2 related tumors.
