Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
70361 | Journal of Molecular Catalysis B: Enzymatic | 2009 | 4 Pages |
Abstract
Enantiomerically enriched 4-phenylpyrrolidin-2-one was prepared within only three steps starting from a commercial compound employing dynamic kinetic resolution (DKR) as the key asymmetric step. To the best of our knowledge, for the first time a DKR was performed involving an enzymatic enantioselective amination reaction catalyzed by ω-transaminases. Careful optimization of co-solvent and pH conditions allowed enhancing the enantioselectivity. The general method allows access to 4-arylpyrrolidin-2-ones derivatives, the cyclic analogues of γ-aminobutyric acid (GABA) derivatives.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Dominik Koszelewski, Dorina Clay, Kurt Faber, Wolfgang Kroutil,