| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 70368 | Journal of Molecular Catalysis B: Enzymatic | 2011 | 5 Pages |
Abstract
Large screening identified lipase AK to be capable of the selective deacetylation of pentaacetyl silybins A and B to yield 3,5,20,23-tetra-O-acetyl-silybins A and B, and 3,20,23-tri-O-acetyl-silybins A and B, respectively. Deacetylation occurred at phenolic OH groups, only. These new compounds prepared from the optically pure silybins can serve as new stereochemically pure synthons for selective silybin modifications.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Selective deacylation of optically pure silybins with lipases. ► Large screening of lipases (24) with a single hit, e.g. lipase AK. ► Detailed kinetic study allowing selective preparation of particular derivatives.
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Authors
Kateřina Purchartová, Petr Marhol, Radek Gažák, Daniela Monti, Sergio Riva, Marek Kuzma, Vladimír Křen,