Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
70439 | Journal of Molecular Catalysis B: Enzymatic | 2010 | 6 Pages |
Abstract
CAL-B lipase-catalyzed resolution of a number of arylalkylethanols using succinic anhydride as acylating agent has been performed to evaluate the corresponding enantioselectivity factors. Then “one-pot multi-substrate screening” reactions involving two- and four-substrate mixtures were carried out and evaluation of the enantioselectivity factors for each alcohol was undertook by a single-run analysis. It was concluded that the alcohols in the mixture behave independently, validating the “one-pot multi-substrate screening” for a rapid evaluation of the enantioselectivity of the kinetic resolution process for each individual substrate.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Hanane Debbeche, Martial Toffano, Jean-Claude Fiaud, Louisa Aribi-Zouioueche,