Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
70543 | Journal of Molecular Catalysis B: Enzymatic | 2009 | 4 Pages |
Abstract
(R)-1-Arylethanols have been prepared in high to excellent overall yields through a two-step one-pot process that involves the palladium-catalyzed conversion of aryl iodides into the corresponding acetophenones, in the presence of acetic anhydride, EtN(i-Pr)2, LiCl, and Pd2(dba)3 followed by an enantioselective reduction step catalyzed by the alcohol dehydrogenase enzyme from Lactobacillus brevis.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Sandro Cacchi, Roberto Cirilli, Giancarlo Fabrizi, Simona Sgalla, Alberto Macone, Alessandra Bonamore, Alberto Boffi,